In the case of RBD, the primary pathology appears to be an excitation/inhibition imbalance in the brainstem nuclei controlling REM muscle tone. Dysregulation, disease or degeneration of these nuclei can result in sleep disorders, such as narcolepsy, and subtle changes to sleep-wake patterns. The behavioral states of wake and sleep are initiated and maintained by complex interplay between multiple brainstem and diencephalic nuclei. The mechanisms behind this fluctuation remains unknown. In any one patient, the severity and frequency of the behaviors may also vary from night to night, and over the course of their condition ( 10). The frequency of motor events may vary greatly between RBD individuals ranging from multiple episodes per night, to one episode per month ( 9). Upon awakening from a large motor event, the RBD individual will be alert and orientated to their surroundings ( 4). When a dream enactment is occurring, the individual's eyes will remain closed as they engage with the dream environment and their movements are generally contained to their immediate surroundings, thus differentiating these episodes from NREM parasomnias such as sleepwalking ( 4). More systematic studies have revealed that violent dreams and behaviors only make up a small percentage of all events ( 6– 8). Whilst accounts of individuals kicking, punching, biting, or even strangling their bedpartners during sleep paint an emotive image of the condition and often capture public interest, they are prone to recall bias. As acute dream enactment is generally self-limiting, the chronicity of symptoms (>6 months) is a key distinguishing factor, and forms part of the diagnostic criteria for RBD ( 4).Īnecdotally, dreams are often reported by patients with RBD as violent or aggressive, resulting in violent motor behaviors which may pose a threat to them or their bedpartner ( 5). In contrast, RBD individuals will maintain REM sleep during and immediately after most of their dream enactments. In non-pathological dream enactment, individuals typically respond to dream content during the transition from REM sleep to the awake state and while maintaining REM atonia during much of the REM period. The same symptoms may also be experienced during withdrawal from sedatives or alcohol. It is important to remember that dream enactment and limb movements during sleep can occur in the healthy population, often in the context of heightened emotional states ( 1– 3). Here, individuals experience vivid dreams which they act out during sleep. Whilst isolated RSWA is frequently an incidental finding in sleep studies, it forms the substrate of the dream enactment behavior which defines RBD. This phenomenon is often referred to as REM Sleep without Atonia (RSWA). Rapid Eye Movement (REM) Sleep Behavior Disorder (RBD) is a non-familial sleep disorder, characterized by the loss of the inherent muscle atonia observed during normal REM sleep. We aim to raise awareness and develop a framework for best practice for RBD patient management. In this review, we summarize RBD pathology and differential diagnoses, diagnostic, and treatment guidelines as well as prognostic recommendations with a look to current research in the scientific field. Both clinicians and patients are therefore forced to deal with uncertain outcomes. There are no binary prognostic markers for RBD disease course and there are no clinical guidelines for neurodegeneration scaling or tracking in these patients. Uncertainty in patient management is further exacerbated by a lack of clinical guidelines for RBD patient care. The disease's low prevalence and the relatively limited awareness of the condition amongst medical professionals makes the diagnosis and treatment of RBD challenging. RBD patients also exhibit accelerated disease progression and a more severe phenotype than α-synucleinopathy sufferers without RBD. RBD patients have a high risk of developing one of the neurodegenerative α-synucleinopathy diseases: over 70% will develop parkinsonism or dementia within 12 years of their diagnosis. Individuals often present to clinic with complaints of injury to themselves or their bed-partner due to violent movements during sleep. REM Sleep Behavior Disorder (RBD) is a chronic sleep condition characterized by dream enactment and loss of REM atonia. 4Translational Health Sciences, University of Bristol, Bristol, United Kingdom.3Department of Neurology, Southmead Hospital, Bristol, United Kingdom.2Rosa Burden Centre, Southmead Hospital, Bristol, United Kingdom.1School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom.
0 Comments
NBA teams averaged 114.7 points per game. Not much was expected of either Sabonis or Kuzma heading into this season-Sabonis struggled to stay on the floor as a rookie, and Kuzma was the 27th overall pick-but in a short time this season, they’ve already proved themselves.Scoring was up in the NBA this season, to a level not seen in more than a half-century. Kyle Kuzma and Domantas Sabonis Are in the Top 15 in Field Goal PercentageĪfter a draft full of promising point guards, this has so far been the Year of the Young 4. Perhaps the bigger issue: Rubio is getting to the line nearly as much as Rudy Gobert is, and he’s making one more free throw per game than the Jazz center. That Rubio, who has never seen a pass he didn’t like, is the Jazz’s leading scorer speaks to both the void left behind by Gordon Hayward and a slight indictment of their lack of a go-to option on offense. And while his 3-ball sunk to below 30 percent after Tuesday’s 0-for-5 performance, he’s firing it up from behind the line 5.2 times a game. On 12.5 shots per game (a career high), Rubio is hitting 39.1 percent of his field goals (just shy of a career high), and averaging 15.8 points per game (a career high). dlK39n8ktc- Anastasio Ríos November 2, 2017 Ricky Rubio está en un nivel que se permite anotar 30 puntos (8/17 TC y 3/6 T3) y dar 1 asistencia. But, please, allow me to introduce Long-Haired Rubio: volume shooter, and the Jazz’s leading scorer You know Hoodie Melo, and now there may be Arm Sleeve Porzingis. Ricky Rubio’s 15.8 Points Per Game Leads the Jazz The Thunder, meanwhile, need every point they can get. This feels like a problem, because we’re not in the preseason. This seems small and meaningless, but as someone who had the same pregame routine before every high school soccer game (totally comparable, I know), I understand. Westbrook said nearly two weeks ago that part of the reason he’s been off is because a change in league rules no longer allows him to walk behind the 3-point line after an attempt. Or, as Westbrook tells it, he’s shooting it a different way. It’s almost like he’s forgotten how to shoot that shot. Last season, for reference, Westbrook was getting to the line 10.4 times a game and shooting 84.5 percent. Westbrook is shooting a strikingly low 60 percent from the charity stripe on 5.5 attempts per game. Russell Westbrook Is Shooting 60 Percent From the Free Throw LineĪfter losing to the Sacramento Kings on Tuesday night, the Oklahoma City Thunder have bigger problems to worry about than Westbrook’s shoddy free throw shooting. The closest Warrior with at least 10 minutes per game is Kevin Durant, who has only a plus-19.9 net rating. Curry is averaging 32.8 minutes per game, with a plus-22.6 net rating. This stat isn’t surprising as much as it is outstanding. Steph Curry /1oB31pV3NY- Tercer Equipo NBA November 7, 2017 Lest we forget, Curry is a destroyer of defenses, an MVP-level player, and now an underrated part of his own championship-level team. You know who could use a few of those shot attempts? Lauri Markkanen. He’s shooting 34.6 percent from the field and 32.9 percent from 3. Somebody’s got to take those leftovers, and so far it’s been Holiday. Taj Gibson, also gone, took more than nine shots a game. Who knew that HBO’s new season of The Leftovers would be based in Chicago, and that Justin Holiday would be playing the lead role? Jimmy Butler and Dwyane Wade, duly departed from a now-rebuilding Bulls team, took 16.5 shots and 15.9 shots, respectively, per game last season. Justin Holiday Is Taking 15.1 Shots a Game (Including 8.4 3s) By playing Tatum and Brown mostly alongside the talented core of Al Horford, who is shooting 47.4 percent from 3 this season, and Kyrie Irving, who has looked efficient in his new home, Brad Stevens is putting both in a position to succeed. The polished Tatum, still just 19 years old, is showing already on the offensive end hints at a higher ceiling ahead. But he’s also getting to the line more than ever. He’s crashing the boards more, and all of his shooting numbers have risen, minus a 58.3 percent mark from the free throw line. nvPx7p3keM- Andrés Villar November 6, 2017īrown’s improvement from last season has been remarkable. Tatum en tres jugadas consecutivas dejando su sello: doble en penetración a mano izquierda, puntea el tiro en defensa y asiste a Horford. Then, _Disappointed But Less Stupid Me_ went into the platform code of libGDX to discover that it _already uses_ stb_image for loading PNG files. According to the profiler, most time here is spent reading and decoding PNG data.Ī few weeks ago, _Stupid Past Me_ went ahead and replaced the libGDX PNG decoder with via LWJGL bindings, just to figure out that this change didn't improve anything. To some extend, the same applies to _loading_ the texture atlas. This is the single most expensive _TexturePacker_ operation. They are saved as PNG files, which compress super nice, but _devour_ CPU time. In fact, the profiler showed that _TexturePacker_ spends almost all of its time in image I/O. _Reading and decoding_ all the tiny PNG files to _fill_ the atlas with pixel data _is slow_. Still, this wasn't the biggest offender by far. Also, it doesn't help that we do this twice: first for checking if something has changed and the atlas needs to be rebuilt, then again with _TexturePacker_ itself. Searching directory trees and collecting all source files is slow, especially on a Windows file system. Surprisingly, my initial assumptions - for example, that the _TexturePacker_ code by itself is slow, because it does _a ton_ of stuff we don't need - was proven wrong. Recently, I sat down again to figure out how to speed up both updating and loading our texture atlases. Load sprites/anims atlas - action executed in 1887 ms After we applied some optimizations to the game loading process during the past few months, it's one of our biggest load-time performance hogs right now. Now, _loading_ sprite sheets is a lot faster of course. Run it on a HDD, and you can go enjoy your coffee break. With a cold file cache, this can take twice as long. This is how it looks today, on an i7-4790K with a decent SSD:Īsset builder executed in 36.162198 seconds But nowadays, _if_ a rebuild is required, it surely takes its time. Early in development of the game, we took some measures to only rebuild assets when needed. At the moment I write this article, Pathway _quadruples_ this size already.īuilding texture atlases of this size is a time-consuming process, as well as loading them. 's previous game,, shipped with an atlas of 11 2048x2048 pages, which approximates about 2 1/2 sheets of size 4096x4096. !(heinrich_atlas.jpg border=1) The tool used to build this atlas is the. In terms, sprite sheets are grouped into what's called a _texture atlas_. For use in the game, they are all gathered in large sprite sheets, which is a common technique to ensure good render performance, as well as to reduce load times. In Pathway, there are many sprites like Heinrich. The other one helps to cast Heinrich's shadow in a plausible manner. One is responsible for making Heinrich look darn handsome when lighted. !(heinrich_siblings.png)Īs a matter of fact, in Pathway, unlike many other pixel art games, Heinrich has two siblings, Heinrich#Normal and Heinrich#Depth. He's a German soldier in our upcoming game. But sometimes, it's worth pushing that direction even if the pain seems. Interestingly, over the years in games development I met many people who are notably resistant to this kind of pain. I've never heard this term before that day, so I don't know if he came up with it by himself, but it surely was fitting at the time and place. > until there is some pain the current approach is In a previous job, one of my fellow co-workers coined the phrase "pain-driven development". In case you were unaware of this, 42 states have enacted laws governing the fees that notaries can charge for their services. The $50 fee charged by the government is actually 10 times more than the maximum notary fee permitted by law in the majority of states in the U.S. I have to admit, I feel a little taken advantage of by Uncle Sam. How Much Does a Notary Cost According to the National Notary Association, most states set a maximum amount notaries can charge for their services. The document that I had required two notary seals, which ended up costing me a jaw-dropping $100 USD. Mortgage closings can cost more than other papers to notarize. In certain states, notaries can set their own fees. The federal government charges it’s citizens abroad $50 per notary seal. Standard notary costs range from 0.25 to 20 and are billed on a per-signature or per-person basis. Sticker ShockĮven though I didn’t expect the notary service to be free, I did expect it to be on par with notary fees in the United States - unfortunately, that wasn’t the case. If you need documents to be notarized or commissioned for private and commercial transactions: check the yellow pages go to your local library and speak to someone about how to find a notary or commissioner in your community A fee may be charged for this service. I made an appointment for the following week and the whole process took less than 10 minutes. In addition to the fee, a notary public may. Pursuant to Rhode Island Notary Public Standards of Conduct, notaries may charge a fee not to exceed 25 per document/notarization All fees must be posted in a. Consular Office was only about 35 minutes away in Playa del Carmen. Idaho Code 51-133 states a Notary public may, for any notarial act, charge a fee not to exceed five dollars (5.00). Since that second option seemed like more of a hassle, I decided to turn to Uncle Sam for some assistance. The Casa del Marino project is already a reality in Mazatlan Notary fees vary depending on which country the notary works in. The goal of Bubble Shooter is to make all of the bubbles on your screen disappear! The way to do this is to get three bubbles of the same color to touch. When you start Bubble Shooter, you’ll notice many bubbles on your screen ready for you to pop them! You’ll have a bubble cannon at the bottom end of the screen with a colored bubble. THE RULES OF BUBBLE SHOOTER - HOW TO PLAY Once you’ve mastered classic Bubble Shooter, try your hand at Bubble EXTREME, Bubble Shooter Pro-or combine TWO all-time classic games with Bubble Shooter CANDY! If you love to spice up your gaming experience, then you’re going to love this place! We’ve built tons of different variations of the classic Bubble Shooter game, so you’ll never get bored. You spoke, and we listened! We’ve upgraded Bubble Shooter so that it can be enjoyed on every single device! Share your score with your friends! Warning: Bubble Shooter is addictive! We want our gamers to immerse themselves into Bubble Shooter, the website with amazing, free online gaming! We inject fun into every single level, every game, and every design. Want to know why Bubble Shooter has been so successful, and beloved by gamers all across the world? It’s because WE, THE DEVELOPERS, LOVE ONLINE GAMES AS MUCH AS YOU DO! We’re gamers ourselves and we understand what it takes for a game to be fun, rewarding, and satisfying! Every single game we built is designed for people who LOVE games. Whether you’re on your lunch break at work, unwinding after a long day, or simply looking for a fun way to pass the time-join us at Bubble Shooter! We’ve built, designed, and given our visitors access to timeless classic games. That means we’ve curated the ULTIMATE free online game experience. You’re our guest, and at Bubble Shooter we like to roll out the red of carpet. You see, we create online games for YOU in mind. Where the goal is to have fun, play some awesome free online games-and keep beating your high score! We believe it’s the simplicity of Bubble Shooter that keeps our gamers coming back! But it’s also the high quality of our games. Welcome to, the home of the bubble shooter game. Go through the door to Transfer Junction. When it hits the second obstruction, interact with the computer in the back of the room to lift the final bridge, allowing it to exit the Supply Depot. Interact with the computer by the Marker to lift the bridges and let it advance down the track. Inside are some more floor chests, lockers, and some Credits.įollow the Locator trail back to the front of the room. Shoot the orange pod as usual to destroy the Tendril, then head outside and make your way to the other Holding Zone 2B door. Look across the room and you will see more loot on the other side, obstructed by a Tendril. Inside are some loose items, two floor chests, and a wall safe containing a Node. Make your way to the back right corner of the room and enter the room labeled Holding Zone 2B. There is one Item Box near the front door and a floor chest behind a box on the middle platform. Once all the enemies are dead you can take some time to loot their corpses, and grab some of the random Ammo and Credits dropped on the floor around the room. There’s not necessarily a free win strategy here, but the basics are to keep moving to prevent yourself from getting surrounded, try and group enemies up and use area of effect attacks, and of course Stasis a lot. Take advantage of these and use Stasis constantly to make the fights easier. One by each of the doors near the front, one on the platform in the middle, and one in the back corner. You need to move various obstructions out of the way so the Marker can pass through, all while dealing with waves of Necromorphs.įirst thing first, take note of the many Stasis Recharge stations in this room. The Supply Depot is very similar to the Loading Bay from the previous chapter. Pass through the Supply Depot door, then use the computer inside to open the next shutter and unlock the way forward. Transport the Marker Through Supply Depotĭeal with any remaining Necromorphs, then use the computer near the tracks to open the shutter and advance the Marker. This powers up the shutter, allowing you to proceed. Take the battery outside and slot it into the wall a short way from the door. Be sure to grab the real prize, a battery. Inside the Server Room is the aforementioned Stasis Recharge station, along with an Item Box, some Credits, and an Audio Log. Last thing you need is more enemies on your hands! Look out for the Infector and deal with it first if you can. It is hard to maneuver in this small space, so be sure to use a lot of Stasis, there is another refill station in the server room. Inside is some more Ammo and Credits, as well as a wall safe in the back corner containing a Node.īe sure to grab this nearby Audio Log before heading back to the Living Quarters.įrom the Living Quarters open the Server Room door, which will trigger a Necromorph ambush. Save your game then go through the door to the Landing Pad Atrium. There is also some Ammo on the floor, as well as Text Log, Retrieval Orders. Head inside to find a Save Station, Store, and Bench. Make your way over to the building next to the tracks with the door labeled Living Quarters. Follow the tracks while staying on the left side and you will find a dead end with some Credits. It will roll down the tracks a short way until it encounters the closed shutter. Return to Nicole and interact with the computer next to her to unload the Marker. Turn around and find this floor chest hidden among some machinery, which contains a Gold Semiconductor. We can provide release forms for this event if necessary.Bill Nye, left, Jerome Foster ll, and Christi Paul, right, along with Jane Fonda who is attending virtually, during the Captain Planet Foundation 30th Anniversary Gala on Saturday, Mar.
You can use the arrow keeps to move the monitors around (in the display settings screen) which sometimes helps. It's possible to have your monitors aligned in display settings where they APPEAR to be perfectly adjacent, but actually aren't - there's a pixel or two of dead space between them. Quote:I've spent a ton of time wrestling with this issue, and I don't think it's related to Windows Snap features. Top is my setup, 2nd one is after I moved monitor 1 with Shift + Right Arrow, and bottom is after I moved monitor 1 with Right Arrow (no shift). I just discovered that if you hold shift when pressing the arrow keys, it seems to move the monitors in very small (single pixel?) increments, which finally did the trick.Īlso, when using the arrow keys to relocate your monitors, one monitor can 'push' another monitor, but it can't push two, so if you have three monitors in a horizontal row, you should try pushing the outside monitors towards the center one.Īttached is an image with examples. I've spent a ton of time wrestling with this issue, and I don't think it's related to Windows Snap features. The Coca-Cola Company never intended on keeping the drink on store shelves long term, and this was obvious by how quickly it sold out in stores, never to be replenished.Īs an homage to the drink, FYE released an exclusive Ecto Thirst Quencher Tropical Soda. It wouldn't be until 2016, with the upcoming new Ghostbusters film, that Ecto Cooler would make a brief marketing campaign comeback. These two variations of flavors are difficult to find (from a collector's perspective).ġ997 - 2001 Shoutin' Orange Tangergreen (left)Īnd 2006 Crazy Citrus Cooler (right) Juice Boxes After a brief hiatus, the flavor returned in 2006 in the form of Crazy Citrus Cooler, but disappeared again after just one year. Slimer was removed from the package in 1997, and the name was changed to Shoutin' Orange Tangergreen until the drink was discontinued in 2001. Even Ecto Cooler itself has made an appearance in the various IDW Ghostbusters titles. It's shown as both ads in the panels of pages, as well as a drink. It got an updated package for the 1996 release, and this one is rather difficult to find these days.Ī fun fact about the drink is that IDW gave it a parodying nod in its 2011 Ghostbusters comic book series under the guise of Slime-C. The drink was so popular among juice enthusiasts, that even when the cartoon series ended in 1991, sales justified it remaining on the market. Definitely recommended that you not drink one if you find it. If you found one of these today, chances are high that it would have turned a disgusting black / purple color. The movie, Ghostbusters II, the cartoon, The Real Ghostbusters, and the drink I somehow missed out on my entire childhood and young teen years, Hi-C's Ecto Cooler.Įcto Cooler made its debut in 1989, and was a repurpose of their already existing flavor, Citrus Cooler, which I also have never had.ĭon't let the delicious green juice in the container above fool you. It was based on one of the most highly anticipated sequels of all time, and went on to remain on store shelves long after the highly popular cartoon series based on that movie, and if you believe it or not, I've never so much as sipped one. It's the juice that defined a generation. Just ignore the "Quantum Break is out now on Steam" part - some things age badly. I liked it and so did RPS’ review, if you'd like to read more about the blockbuster. Even though it’s a little tamer than Control and Alan Wake, it was still a fun and slick adventure. The Remedy weirdness was relegated to live-action episodes that slightly differed depending on a few choices you made. Things go terribly wrong, his brother (Merry the Hobbit) kinda dies, and Jack's soon embroiled in a reality-breaking conspiracy. Jack Joyce (Iceman) helps out an old friend (Little Finger) with some shady research. Hopefully, Jack Joyce and the gang escape time limbo quicker.Įven for time-hopping, denim-clad scientists, 2016 feels like a lifetime ago, so I’ll refresh your memory on Quantum Break. Alan sank into the lake’s deep emptiness for over a year, but he eventually came back to storefronts, no problem. Those bad seeds were previously responsible for killing Alan Wake (also temporarily) when the action-horror was removed from sale in 2017. Quantum Break featured a number of real-world music tracks that bookended each chapter, including songs from Paramore, Toto ( that Toto track), and Nick Cave & The Bad Seeds. Update: Xbox games marketing VP Aaron Greenberg has now weighed in on the situation, confirming that Quantum Break's removal from Game Pass is temporary and it will be coming back to the service. We’ve reached out to Remedy for clarification, but a safe assumption to make is that the same licensing issues affecting the Game Pass release also affected Quantum Break’s listing on storefronts. The inevitable flow of time affects all things - trees stretch to the sky only to be chainsawed down, stars fold inward and collapse, and much like a human life cycle, licences end and kill games - sometimes temporarily. Will let you know as soon as it is back.” Publisher Microsoft had already confirmed the game would be “temporarily” removed from Game Pass (for console, it was never on the PC version) due to licensing issues, although there was no word on a removal from storefronts.Įarlier this week, Xbox’s head of marketing Aaron Greenberg said “Don’t worry Quantum Break will be coming back to Game Pass.” He explained that “It is being temporarily removed due to some licenses that expired that were in the process of being renewed. The game’s Steam page is still up, but it’s no longer available for purchase on PC or Xbox consoles. Jack Joyce has run out of time, or steam, both work! Remedy’s time-bending Quantum Break - part superpowered shooter, part live-action TV show - has been delisted on Steam and The Microsoft Store. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |